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Cardiology

Heart Failure and Cardiac Transplantation

• Pediatric Heart Transplant Data Registry -- a prospective multicenter data registry with 23 participating centers of all patients less than 18 years old who are listed for cardiac transplantation with UNOS through our institution. Contact: Linda J. Addonizio, MD
• Genetic Contributions to Graft and Patient Outcomes -- a NIH-funded multicenter study at six large North American pediatric transplant centers. This study addresses how three genetically determined variables -- HLA incompatibility, mediators of inflammation, and immunosuppressive drug efficacy -- influence cardiac transplantation outcome in pediatric patients. Contact: Linda J. Addonizio, MD
• Pediatric Cardiomyopathy Registry Cohort Study Protocol -- a prospective cohort study followed at up to 15 clinical centers in the United States. This study aims to collect clinical and echocardiographic data on the course and outcomes of cardiomyopathy in a cohort of children; and to establish the longitudinal course of functional status in children with cardiomyopathy, and analyze the relationship to clinical events and outcomes. Contact: Linda J. Addonizio, MD
• Alloantibodies in Cardiac Transplantation -- a NIH-funded multicenter study (CTOTC) with the primary objective to determine the clinical outcomes of sensitized pediatric heart transplant recipients with a positive donor-specific cytotoxicity cross-match and to compare them with outcomes in non-sensitized participants. Contact: Linda J. Addonizio, MD
• Interagency Registry of Mechanically Assisted Circulatory Support -- a national, prospective registry of hospitals implanting durable mechanical support devices that will contain clinical and follow-up data, including death, explant, rehospitalization, and three adverse advents: neurological dysfunction, infection, and device malformation. Contact: Jonathen Chen, MD
• Quality of Life Assessment in the Pediatric Cardiac Population -- a multicenter study in the United States and England to test the scores generated by the Pediatric Cardiac Quality of Life Inventory (PCQLI) in children and adolescents with acquired and congenital heart disease. Contact: Marc Richmond, MD
• Pediatric Cardiomyopathy Biologic Specimen Repository -- a study at up to 15 selected Pediatric Cardiomyopathy Registry (PCMR) clinical centers to collect samples from children with cardiomyopathy who are participating in some aspect of PCMR research. In the future, these samples will be available to investigators who propose studies requiring use of biologic specimens that are approved by a repository access committee. Contact: Linda J. Addonizio, MD
• Evaluating the Usefulness of Cardiac PET Imaging in Detecting Coronary Vasculopathy in Pediatric Heart Transplant Patients -- a pilot study to evaluate 13N-NH3 cardiac PET imaging to evaluate coronary flow reserve and prevalence of microvascular disease in pediatric cardiac transplant patients with and without coronary vasculopathy. Contact: Rakesh Singh, MD
• Size-Matching for Pediatric Cardiac Transplantation -- a retrospective review to determine the usefulness of donor characteristics, including bodyweight, as criteria for size matching. A secondary study will be performed to the normal range for the distance between the right atrium-superior vena cava junction to the right atrium-inferior vena cava junction. The potential benefit is the ability to more appropriately size-match donors for heart transplants to recipients. Contacts: Jonathen Chen, MD and Marc Richmond, MD
• Red Blood Cell Distribution Width as a Predictor of Outcomes in Pediatric Heart Failure -- a retrospective review of patients younger than 25 years old with clinical heart failure or pulmonary hypertension to determine whether the presence of anemia and/or an elevated RDW may be useful in predicting adverse outcomes. Contact: Linda J. Addonizio, MD
• Outcomes of Surgical Treatment for Hypertrophic Obstructive Cardiomyopathy -- a retrospective chart review of pediatric patients with hypertrophic obstructive cardiomyopathy who underwent left ventricular septal myomectomy and/or mitral valve replacement. Contact: Linda J. Addonizio, MD
• Impact of Immunosuppressive Therapy and EBV Status on Risk of Post Transplant Lymphoproliferative Disease -- a two-center (Children's Hospital of New York Presbyterian and the Royal Children's Hospital in Melbourne, Australia) retrospective chart review of pediatric patients who underwent heart transplantation to examine the impact of type of immunosuppression therapy and donor and recipient EBV status in relation to risk of subsequent PTLD. Contact: Linda J. Addonizio, MD
• BNP and Pediatric Heart Failure -- a post-hoc analysis of data from the "Multicenter, placebo-controlled, 8-month study of the effect of twice daily carvedilol in children with congestive heart failure due to systemic ventricular systolic dysfunction." The goal of this study is to determine whether BNP increases with increasing clinical severity of heart failure. Contact: Linda J. Addonizio, MD
• Predictors of Outcome in Ventricular Non-Compaction -- a retrospective review of all patients identified with non-compaction of the myocardium at the Children's Hospital of New York Presbyterian. The primary outcome measures are overall survival and transplant-free survival time from diagnosis. Contact: Marc Richmond, MD
• Hepatitis C Virus Infection in Heart Transplant Recipients -- a retrospective study to characterize the effect of HCV infection on both mortality and the incidence of post-transplant complications in children. Contact: Linda J. Addonizio, MD
• Risk Factors in Pediatric Cardiac Transplantation -- a retrospective review of all patients who underwent heart transplantation at the Children's Hospital of New York Presbyterian to determine risk factors for mortality and graft loss. Contact: Linda J. Addonizio, MD