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Cardiology

Developmental Biology

In the Developmental Biology research program within the Division of Cardiology, we aim to further our understanding of the genetic determinants of cardiac morphogenesis through the study of model organisms. The transparent zebrafish embryo is ideal, as it allows for microscopic observation of the developing heart throughout embryogenesis. Furthermore, Zebrafish do not require a functional cardiovascular system for survival until well after cardiac chamber formation is complete. The large volume of embryos that are readily obtained in the laboratory provides us with a powerful tool for genetic analysis. Currently, our research is focused on the study of NKX2.5, a cardiac-specific homeodomain transcription factor that is known to cause different types of heart defects. As additional causative genes are identified in human genetics, we will take advantage of the benefits of the zebrafish model as a means to understand the mechanisms underlying congenital heart disease. Contact: Kimara L. Targoff, MD

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